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pentobarbital will reduce the extent or effect of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with sturdy CYP3A4 inducers just isn't encouragedpentobarbital will minimize the extent or effect of ibuprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Minor/Significance Unfamiliar.pe